What does bioavailability mean?

Many factors play into bioavailability and finding highly bioavailable products is a great way to ensure your body is getting what it needs.

The world of health and wellness can sometimes make you feel as though you need to go back to school. Terms like oxidative stress, mitochondria, and bioavailability can seem overwhelming at first but while there is some basic anatomy and physiology knowledge that is needed, the truth is that you don't need a biology degree to get your health and wellness sorted. After learning these terms, you'll be well on your way to understanding up-to-date research and choosing the best route for you to attain good health and make informed decisions.

Put simply, bioavailability is the measure of how much of a consumed/administered molecule is available to the cells that need it within your body.

What you put into your body is important and we understand that so we've put together this article so you can look at the concept of bioavailability, how it is measured, why it matters, and when it is utilized. Understanding bioavailability and what it means can allow you to be a more informed consumer and ensure you are getting the very best supplements and nutrition to support your body through your workouts and daily life.

What is bioavailability?

Bioavailability is a measure of the amount of a molecule that is available and utilized by the body when it is taken. The human body has a very specific mode of obtaining and utilizing molecules. Simple changes to molecules can result in them not being utilized by the cells in the body.

Another aspect of bioavailability is how much of the compound actually gets to where it needs to within the body. With compounds taken orally, the digestive tract is full of enzymes, acids, and other molecules that can alter the molecule and decrease its effective absorption. Some routes of administration forgo the digestive tract for this reason and need to be injected.

This is a major reason why things like insulin are only available in injections and not through oral medications. Other methods include the addition of chemical compounds to help the absorption or protection of a specific molecule as it goes through the digestive tract.

How is bioavailability measured?

Bioavailability is measured by assessing the amount of a molecule given and comparing that amount to the levels that are utilized by the body. The way that bioavailability is calculated depends on the route of administration and the intended target of the molecule.

For medications or supplements, the amount taken can be compared to the level found circulating within your blood after digestion.

Bioavailability can be quantified in multiple ways. One of which is by dividing the amount of a molecule given by the amount of it that is absorbed into the body. Multiplying this fraction by 100 gives you the percentage of bioavailability. The closer the value is to 100%, the more bioavailable it is.

Why does bioavailability matter?

The main reason drug bioavailability matters is that it provides information on how effective a particular supplement or treatment is. The amount that is described on a bottle or packaging only gives you half the story.

As a health-conscious consumer, it is important to understand that quantity is not the definitive answer as to whether a product is good or not. Taking the bioavailability of products into consideration means that you are looking at what your body is getting out of something per serving. Bioavailability is a good measure of quality - and quality is much more important when compared to quantity.

When is bioavailability used?

The measure of bioavailability is used to describe the pharmacology of drugs, to better understand nutrition, and to evaluate supplements. Taking bioavailability into consideration, whether you are a healthcare professional or a health fanatic, is important in ensuring the body is getting exactly what it needs when it needs it.

Medicines

Assessing the bioavailability of medicines is an important aspect of ensuring an individual gets the correct dosage of a certain medication. A large part of medicine development is finding the therapeutic dose or the amount of medicine that leads to the largest benefit.

For drugs with a relatively narrow therapeutic index, bioavailability differences can also cause substantial therapeutic nonequivalence. With knowledge of bioavailability and what can affect drug bioavailability, pharmaceutical companies can create drug formulations and administer proper drug therapy, and also be able to anticipate possible drug interactions. (Jennifer Le, PharmD, MAS, BCPS-ID, FIDSA, FCCP, FCSHP.MSD Manual.2022.)

Because many oral medicines do not have 100% bioavailability, the developers need to determine what the drug absorption percentage is and designate the dose accordingly.

Nutrients

Nutrition is an important aspect of your day-to-day life. Many food scientists and nutritionists will analyze the bioavailability of nutrients found within food to gain a better understanding of how to ensure people are effectively getting the necessary nutrients into their bodies.

One example of how bioavailability plays a role in your diet is to consider antioxidants, phytates, and polyphenols. These molecules decrease in bioavailability the more they are processed. Some other nutrients found in foods may increase bioavailability when they are cooked rather than eaten raw.

The complex nature of nutrient bioavailability is a large reason people seek the professional assistance of nutritionists. With an education that takes into account the best ways to get the most out of the food you eat, such as their knowledge of nutrient molecules, nutrient absorption, and what can affect absorption, nutritionists can be an extremely valuable resource in anyone's health journey.

Supplements

Nutritional supplements can be somewhat of a wild west in terms of trustworthiness due to some companies not backing their products with scientific evidence. Protein powders, as an example, can state that there is 24g of protein per serving, but that may not correlate to the amount your body can use. Even worse, some deceptive supplements may mislead you- - which could potentially be harmful.

While the FDA has guidelines for consumers, it's ultimately your job to carry out the due diligence to ensure what you are putting into your body is safe.

When looking for supplements, it's important to find quality and reputable supplement companies that hand over their products to non-affiliated labs, provide ample science-backed information, and only use the highest quality and best bioavailable ingredients available.

MitoQ does just that and provides only the highest quality and science-backed ingredients in a two-pill dose. With over 750 peer-reviewed papers and GMP (Good Manufacturing Practice) certified facilities, MitoQ is a brand you can trust.

Bioavailability and CoQ10

Many people looking to better their cellular health start by supporting their mitochondrial functioning. The mitochondria is the powerhouse of the cell and is responsible for providing the usable form of energy for cells to function at their best.

Age and other stressors can decrease the concentration of the antioxidant known as ubiquinone (CoQ10) in the mitochondrial membrane. With a lower concentration of CoQ10, free radical byproducts of cellular respiration can damage the mitochondrial membrane and lead to decreased mitochondrial efficiency.

Many CoQ10 supplements simply take ubiquinol and slap it into a capsule for you to take. While it would make sense for CoQ10 to increase mitochondrial CoQ10 concentrations, in reality, it's not that effective.

CoQ10 is a large, oily, sticky molecule that is very hard to transport across cellular membranes – it's therefore difficult for your body to absorb. Mitochondria create CoQ10 internally for this very reason - because if it was made externally, it would have a tough time getting inside the mitochondria. This is also true for standard CoQ10 supplements - they find it difficult to get inside the mitochondria from the outside due to their large molecule size. Imagine trying to get through a window much smaller than you - it would be a struggle, to say the least! ⁣

MitoQ is a miniaturized and positively charged form of CoQ10. Our mitochondria are negatively charged (remember positive and negative charges attract!) so MitoQ is actively drawn into the mitochondria hundreds of times more effectively than regular CoQ10.⁣ This process means that MitoQ is one of the most bioavailable mitochondrial antioxidants available.

Conclusion

Bioavailability is a term utilized to describe how much of something you take is available to your body to use. This concept is utilized by medical professionals, nutritionists, and health-savvy consumers to have a better understanding of how the body utilizes what it consumes.

When trying to get your health and nutrition where you want it to be, considering the bioavailability of what you are consuming can enable you to make choices that will yield the best results. Whether you are trying to lock in your macros, or are trying to find the best quality supplements, the concept of bioavailability can help you to make the best choices for your needs.

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